Anxiety & Depression 5-HTTLPR Test

If anxiety or depression runs in your family, your DNA may hold important clues. This test analyzes the 5-HTTLPR region of the SLC6A4 gene, which regulates serotonin transport in the brain—a key player in mood, stress response, and emotional wellbeing.

People who inherit the “short” version, often called the “grouchy” gene, tend to produce less of the serotonin transporter protein, which is associated with a higher risk of anxiety, depression, impulsive behavior, and reduced response to SSRI antidepressants. Knowing whether you carry this variant can help you and your healthcare provider make more informed decisions about mental health support, treatment, and medication.